InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NLRP2

Summary

InnateDB Protein

IDBP-69887.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRP2

Protein Name

NLR family, pyrin domain containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000344074

InnateDB Gene

IDBG-69883 (NLRP2)

Protein Structure

UniProt Annotation

Function

Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. {ECO:0000269PubMed:15456791}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15030775, ECO:0000269PubMed:15456791}.

Disease Associations

Tissue Specificity

Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain. {ECO:0000269PubMed:15456791}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0032090	Pyrin domain binding

Biological Process

GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0050718	positive regulation of interleukin-1 beta secretion

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR004020 DAPIN domain
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02758

PRINTS

PIRSF

SMART

SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NX02