Version 5.4
Bos taurus Protein: ARAP3
Summary
InnateDB Protein IDBP-698895.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARAP3
Protein Name ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000021198
InnateDB Gene IDBG-646120 (ARAP3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060 ARF GTPase activator activity
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
Biological Process
GO:0007165 signal transduction
GO:0008360 regulation of cell shape
GO:0030336 negative regulation of cell migration
GO:0032321 positive regulation of Rho GTPase activity
GO:0035021 negative regulation of Rac protein signal transduction
GO:0035024 negative regulation of Rho protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0001726 ruffle
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID
InterPro IPR000159 Ras-association
IPR000198 Rho GTPase-activating protein domain
IPR001660 Sterile alpha motif domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
PFAM PF00788
PF00620
PF00169
PF07647
PF00536
PRINTS
PIRSF
SMART SM00314
SM00324
SM00454
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BBA0
UniProt Splice Variant
Entrez Gene 100337193
UniGene
RefSeq XP_003586355
HUGO HGNC:24097
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02020440 DAAA02020441 DAAA02020442 DAAA02020443
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca