Version 5.4
Bos taurus Gene: ARAP3
Summary
InnateDB Gene IDBG-646120.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARAP3
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015938
Encoded Proteins
IDBP-698895
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120318:
This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:54377030-54453900
Strand Reverse strand
Band
Transcripts
ENSBTAT00000021198 ENSBTAP00000021198
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060 ARF GTPase activator activity
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
Biological Process
GO:0007165 signal transduction
GO:0008360 regulation of cell shape
GO:0030336 negative regulation of cell migration
GO:0032321 positive regulation of Rho GTPase activity
GO:0035021 negative regulation of Rac protein signal transduction
GO:0035024 negative regulation of Rho protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0001726 ruffle
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0030027 lamellipodium
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000120318
View Gene Order
ENSMUSG00000024451
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04144
Endocytosis pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
pi3kcipathway
Class I PI3K signaling events
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL E1BBA0
UniProt Splice Variant
Entrez Gene 100337193
UniGene
RefSeq XM_003586307
HUGO HGNC:24097
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02020440 DAAA02020441 DAAA02020442 DAAA02020443
GenPept
RNA Seq Atlas 100337193

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca