InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TREX1

Summary

InnateDB Protein

IDBP-698907.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TREX1

Protein Name

three prime repair exonuclease 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011063

InnateDB Gene

IDBG-646133 (TREX1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0004527	exonuclease activity
GO:0005515	protein binding
GO:0008296	3'-5'-exodeoxyribonuclease activity
GO:0008408	3'-5' exonuclease activity
GO:0032405	MutLalpha complex binding
GO:0032407	MutSalpha complex binding
GO:0032558	adenyl deoxyribonucleotide binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006259	DNA metabolic process
GO:0035458	cellular response to interferon-beta
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

InterPro

IPR006055 Exonuclease
IPR012337 Ribonuclease H-like domain

PFAM

PRINTS

PIRSF

SMART

SM00479

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q5E9M7

UniProt Splice Variant

Entrez Gene

282099

UniGene

Bt.7472

RefSeq

NP_776900

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BT020893 DAAA02054432

GenPept

AAX08910