InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CCR5

Summary

InnateDB Protein

IDBP-699031.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR5

Protein Name

C-C chemokine receptor type 5

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010652

InnateDB Gene

IDBG-646247 (CCR5)

Protein Structure

UniProt Annotation

Function

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity
GO:0019957	C-C chemokine binding
GO:0071791	chemokine (C-C motif) ligand 5 binding

Biological Process

GO:0000165	MAPK cascade
GO:0006816	calcium ion transport
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019722	calcium-mediated signaling
GO:0023052	signaling
GO:0070098	chemokine-mediated signaling pathway
GO:0070723	response to cholesterol
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR002236 CC chemokine receptor 1
IPR002237 CC chemokine receptor 2
IPR002240 CC chemokine receptor 5
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00241
PR00237
PR00657
PR01106
PR01107
PR01110

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2HJ17