InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CCR5

Summary

InnateDB Gene

IDBG-646247.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR5

Gene Name

C-C chemokine receptor type 5

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008099

Encoded Proteins

IDBP-699031

C-C chemokine receptor type 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160791:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:53598839-53602003

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000010652

ENSBTAP00000010652

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity
GO:0019957	C-C chemokine binding
GO:0071791	chemokine (C-C motif) ligand 5 binding

Biological Process

GO:0000165	MAPK cascade
GO:0006816	calcium ion transport
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019722	calcium-mediated signaling
GO:0023052	signaling
GO:0070098	chemokine-mediated signaling pathway
GO:0070723	response to cholesterol
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane