Version 5.4
Bos taurus Protein: GCHFR
Summary
InnateDB Protein IDBP-699044.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCHFR
Protein Name GTP cyclohydrolase 1 feedback regulatory protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017922
InnateDB Gene IDBG-646259 (GCHFR)
Protein Structure
UniProt Annotation
Function Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Nucleus membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0009890 negative regulation of biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030425 dendrite
GO:0031965 nuclear membrane
GO:0042470 melanosome
Protein Structure and Domains
PDB ID
InterPro IPR009112 GTP cyclohydrolase I, feedback regulatory protein
PFAM PF06399
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32L41
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 617650
UniGene Bt.39011
RefSeq NP_001107998
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109778
GenPept AAI09779

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca