Version 5.4
Bos taurus Gene: GCHFR
Summary
InnateDB Gene IDBG-646259.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCHFR
Gene Name GTP cyclohydrolase 1 feedback regulatory protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013477
Encoded Proteins
IDBP-699044
GTP cyclohydrolase 1 feedback regulatory protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137880:
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:36425458-36429223
Strand Forward strand
Band
Transcripts
ENSBTAT00000017922 ENSBTAP00000017922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0009890 negative regulation of biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030425 dendrite
GO:0031965 nuclear membrane
GO:0042470 melanosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000137880
View Gene Order
ENSMUSG00000046814
View Gene Order
Pathways
NETPATH
REACTOME
REACT_226352
eNOS activation and regulation pathway
REACT_220341
Metabolism of nitric oxide pathway
REACT_219139
Metabolism pathway
REACT_217517
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111176
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_12389
eNOS activation and regulation pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_111217
Metabolism pathway
REACT_199047
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_204801
eNOS activation and regulation pathway
REACT_188937
Metabolism pathway
REACT_208364
Metabolism of nitric oxide pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.39011
RefSeq NM_001114526
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca