Version 5.4
Bos taurus Protein: GHRL
Summary
InnateDB Protein IDBP-699100.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GHRL
Protein Name Appetite-regulating hormoneGhrelinObestatin
Synonyms Gh1-1;
Species Bos taurus
Ensembl Protein ENSBTAP00000041811
InnateDB Gene IDBG-646311 (GHRL)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0016608 growth hormone-releasing hormone activity
GO:0030296 protein tyrosine kinase activator activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0001937 negative regulation of endothelial cell proliferation
GO:0008154 actin polymerization or depolymerization
GO:0008343 adult feeding behavior
GO:0009725 response to hormone
GO:0016358 dendrite development
GO:0032100 positive regulation of appetite
GO:0032691 negative regulation of interleukin-1 beta production
GO:0040013 negative regulation of locomotion
GO:0042127 regulation of cell proliferation
GO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep
GO:0042536 negative regulation of tumor necrosis factor biosynthetic process
GO:0043066 negative regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045409 negative regulation of interleukin-6 biosynthetic process
GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0046697 decidualization
GO:0050728 negative regulation of inflammatory response
GO:0051461 positive regulation of corticotropin secretion
GO:0051464 positive regulation of cortisol secretion
GO:0051965 positive regulation of synapse assembly
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060124 positive regulation of growth hormone secretion
GO:0061098 positive regulation of protein tyrosine kinase activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0030424 axon
Protein Structure and Domains
PDB ID
InterPro IPR005441 Preproghrelin peptide
IPR006737 Motilin/ghrelin-associated peptide
IPR006738 Motilin/ghrelin
PFAM PF04643
PF04644
PRINTS PR01624
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q6SLG7
UniProt Splice Variant
Entrez Gene 281192
UniGene Bt.8142
RefSeq XP_005223078
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY455979 BC148027 DAAA02054528 JQ290373 JQ290374
GenPept AAI48028 AAS67345 AFC75924 AFC75925

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca