InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GHRL

Summary

InnateDB Protein

IDBP-699101.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GHRL

Protein Name

Appetite-regulating hormoneGhrelinObestatin

Synonyms

Gh1-1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016350

InnateDB Gene

IDBG-646311 (GHRL)

Protein Structure

UniProt Annotation

Function

Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity). {ECO:0000250}.Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0016608	growth hormone-releasing hormone activity
GO:0030296	protein tyrosine kinase activator activity
GO:0031768	ghrelin receptor binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001937	negative regulation of endothelial cell proliferation
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008154	actin polymerization or depolymerization
GO:0009725	response to hormone
GO:0016358	dendrite development
GO:0032024	positive regulation of insulin secretion
GO:0032095	regulation of response to food
GO:0032097	positive regulation of response to food
GO:0032691	negative regulation of interleukin-1 beta production
GO:0042127	regulation of cell proliferation
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process
GO:0043066	negative regulation of apoptotic process
GO:0043627	response to estrogen
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0046676	negative regulation of insulin secretion
GO:0046697	decidualization
GO:0050728	negative regulation of inflammatory response
GO:0051965	positive regulation of synapse assembly
GO:0061098	positive regulation of protein tyrosine kinase activity