InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SPARC

Summary

InnateDB Protein

IDBP-699136.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPARC

Protein Name

SPARC

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019758

InnateDB Gene

IDBG-646341 (SPARC)

Protein Structure

UniProt Annotation

Function

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269PubMed:2982834}. Note=In or around the basement membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0007165	signal transduction
GO:0042127	regulation of cell proliferation
GO:0060348	bone development
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR002350 Kazal domain
IPR003645 Follistatin-like, N-terminal
IPR015369 Follistatin/Osteonectin EGF domain
IPR019577 SPARC/Testican, calcium-binding domain

PFAM

PF00050
PF07648
PF09289
PF10591

PRINTS

PIRSF

SMART

SM00280
SM00274

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13213