InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SPARC

Summary

InnateDB Gene

IDBG-646341.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPARC

Gene Name

SPARC

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014835

Encoded Proteins

IDBP-699136

SPARC

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113140:
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:64878194-64900828

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000019758

ENSBTAP00000019758

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0007165	signal transduction
GO:0042127	regulation of cell proliferation
GO:0060348	bone development
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0031012	extracellular matrix