InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: G3BP

Summary

InnateDB Protein

IDBP-699139.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

G3BP

Protein Name

Ras GTPase-activating protein-binding protein 1

Synonyms

G3BP;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000027067

InnateDB Gene

IDBG-646344 (G3BP)

Protein Structure

UniProt Annotation

Function

May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells (By similarity). Cytosolic and partially nuclear in resting cells. Recruited to stress granules (SGs) upon either arsenite or high temperature treatment. Recruitment to SGs is influenced by HRAS (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0004386	helicase activity
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006810	transport
GO:0008152	metabolic process
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR002075 Nuclear transport factor 2
IPR018222 Nuclear transport factor 2, eukaryote

PFAM

PF00076
PF02136

PRINTS

PIRSF

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q32LC7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

534214

UniGene

Bt.5197

RefSeq

NP_001032700

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC109645

GenPept

AAI09646