InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: G3BP

Summary

InnateDB Gene

IDBG-646344.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

G3BP

Gene Name

Ras GTPase-activating protein-binding protein 1

Synonyms

G3BP

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020309

Encoded Proteins

IDBP-699139

Ras GTPase-activating protein-binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25520508

[Homo sapiens] EIF2AK2 (PKR) is recruited to stress granules by G3BP1 to promote innate immune responses at both transcriptional and translational levels.

PMID 25784705

[Homo sapiens] The G3BP1-CAPRIN1-PRKRA complex represents a new mode of PRKRA activation and links stress responses with innate immune activation through PRKRA without a requirement for foreign double-stranded RNA pattern recognition.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145907:
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3\'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:64976048-65004834

Strand

Forward strand

Band

Transcripts

ENSBTAT00000027067

ENSBTAP00000027067

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0004386	helicase activity
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006810	transport
GO:0008152	metabolic process
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000145907

View Gene Order

ENSMUSG00000018583

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_6

KitReceptor pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q32LC7

TrEMBL

UniProt Splice Variant

Entrez Gene

534214

UniGene

Bt.5197

RefSeq

NM_001037611

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC109645

GenPept

AAI09646

RNA Seq Atlas

534214