InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RHO

Summary

InnateDB Protein

IDBP-699145.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHO

Protein Name

Rhodopsin

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001730

InnateDB Gene

IDBG-646351 (RHO)

Protein Structure

UniProt Annotation

Function

Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia. {ECO:0000250}.

Disease Associations

Tissue Specificity

Rod shaped photoreceptor cells which mediates vision in dim light.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008020	G-protein coupled photoreceptor activity
GO:0009881	photoreceptor activity
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0007603	phototransduction, visible light
GO:0009416	response to light stimulus
GO:0009583	detection of light stimulus
GO:0018298	protein-chromophore linkage
GO:0043547	positive regulation of GTPase activity
GO:0050896	response to stimulus
GO:0050909	sensory perception of taste
GO:0050953	sensory perception of light stimulus
GO:0060041	retina development in camera-type eye
GO:0071482	cellular response to light stimulus

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042622	photoreceptor outer segment membrane
GO:0060342	photoreceptor inner segment membrane
GO:0097381	photoreceptor disc membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000732 Rhodopsin
IPR001760 Opsin
IPR007960 Mammalian taste receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019427 7TM GPCR, serpentine receptor class w (Srw)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
IPR019477 Rhodopsin, N-terminal

PFAM