InnateDB Protein
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IDBP-69918.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TRPM3
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Protein Name
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transient receptor potential cation channel, subfamily M, member 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000366315
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InnateDB Gene
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IDBG-69916 (TRPM3)
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Protein Structure
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Function |
Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. {ECO:0000269PubMed:12672799, ECO:0000269PubMed:12672827}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:12672827}; Multi-pass membrane protein {ECO:0000269PubMed:12672827}.
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Disease Associations |
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Tissue Specificity |
Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. {ECO:0000269PubMed:12672799, ECO:0000269PubMed:12672827}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005821
Ion transport domain
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PFAM |
PF00520
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9HCF6
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PhosphoSite |
PhosphoSite-Q9HCF6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
80036
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UniGene |
Hs.47288
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RefSeq |
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HUGO |
HGNC:17992
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OMIM |
608961
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CCDS |
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HPRD |
10605
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IMGT |
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EMBL |
AB046836
AB099661
AB099662
AB099663
AB099664
AB099665
AF536748
AF536749
AF536750
AF536751
AF536752
AF536753
AJ505025
AJ505026
AL136545
AL159990
AL160273
AL161913
AL356318
AL358786
AL391819
AL442645
AL592438
BC121821
BC134414
BC142972
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GenPept |
AAI21822
AAI34415
AAI42973
AAO49153
AAO49154
AAO49155
AAO49156
AAO49157
AAO49158
BAB13442
BAC55102
BAC55103
BAC55104
BAC55105
BAC55106
CAB66480
CAD43604
CAD43605
CAI12193
CAI96096
CAM13096
CAM13169
CAM15782
CAM17596
CAM22746
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