InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TRIM9

Summary

InnateDB Protein

IDBP-699274.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM9

Protein Name

E3 ubiquitin-protein ligase TRIM9

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013346

InnateDB Gene

IDBG-646464 (TRIM9)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton. Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030425	dendrite
GO:0031410	cytoplasmic vesicle
GO:0042995	cell projection
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003649 B-box, C-terminal
IPR003877 SPRY domain
IPR003961 Fibronectin, type III
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR011011 Zinc finger, FYVE/PHD-type

PFAM

PF00643
PF13639
PF14634
PF00622
PF00041
PF01108

PRINTS

PIRSF

SMART

SM00336
SM00184
SM00502
SM00449
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q29RQ5