Version 5.4
Homo sapiens Protein: TRPM3
Summary
InnateDB Protein IDBP-69934.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPM3
Protein Name transient receptor potential cation channel, subfamily M, member 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355395
InnateDB Gene IDBG-69916 (TRPM3)
Protein Structure
UniProt Annotation
Function Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. {ECO:0000269PubMed:12672799, ECO:0000269PubMed:12672827}.
Subcellular Localization Membrane {ECO:0000269PubMed:12672827}; Multi-pass membrane protein {ECO:0000269PubMed:12672827}.
Disease Associations
Tissue Specificity Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. {ECO:0000269PubMed:12672799, ECO:0000269PubMed:12672827}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0006812 cation transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HCF6
PhosphoSite PhosphoSite-Q9HCF6
TrEMBL
UniProt Splice Variant
Entrez Gene 80036
UniGene Hs.47288
RefSeq NP_996831
HUGO HGNC:17992
OMIM 608961
CCDS CCDS6637
HPRD 10605
IMGT
EMBL AB046836 AB099661 AB099662 AB099663 AB099664 AB099665 AF536748 AF536749 AF536750 AF536751 AF536752 AF536753 AJ505025 AJ505026 AL136545 AL159990 AL160273 AL161913 AL356318 AL358786 AL391819 AL442645 AL592438 BC121821 BC134414 BC142972
GenPept AAI21822 AAI34415 AAI42973 AAO49153 AAO49154 AAO49155 AAO49156 AAO49157 AAO49158 BAB13442 BAC55102 BAC55103 BAC55104 BAC55105 BAC55106 CAB66480 CAD43604 CAD43605 CAI12193 CAI96096 CAM13096 CAM13169 CAM15782 CAM17596 CAM22746

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca