Version 5.4
Bos taurus Protein: ANXA2
Summary
InnateDB Protein IDBP-699393.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANXA2
Protein Name Annexin A2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012655
InnateDB Gene IDBG-646575 (ANXA2)
Protein Structure
UniProt Annotation
Function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome {ECO:0000250}. Note=In the lamina beneath the plasma membrane.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.
Predicted by orthology
Total 68 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0004859 phospholipase inhibitor activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008092 cytoskeletal protein binding
GO:0019834 phospholipase A2 inhibitor activity
GO:0044548 S100 protein binding
GO:0044822 poly(A) RNA binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001765 membrane raft assembly
GO:0006900 membrane budding
GO:0030199 collagen fibril organization
GO:0031214 biomineral tissue development
GO:0031340 positive regulation of vesicle fusion
GO:0036035 osteoclast development
GO:0042730 fibrinolysis
GO:0043086 negative regulation of catalytic activity
GO:0051099 positive regulation of binding
GO:0051290 protein heterotetramerization
GO:0070509 calcium ion import
GO:0071229 cellular response to acid
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005811 lipid particle
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0019897 extrinsic component of plasma membrane
GO:0030496 midbody
GO:0031902 late endosome membrane
GO:0031988 membrane-bounded vesicle
GO:0035749 myelin sheath adaxonal region
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0043220 Schmidt-Lanterman incisure
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
GO:0065010 extracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001464 Annexin
IPR002389 Annexin, type II
IPR002392 Annexin, type V
IPR018502 Annexin repeat
PFAM PF00191
PRINTS PR00196
PR00198
PR00201
PIRSF
SMART SM00335
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04272
PhosphoSite PhosphoSite-P04272
TrEMBL
UniProt Splice Variant
Entrez Gene 282689
UniGene Bt.4314
RefSeq NP_777141
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102516 BT021010 M14056
GenPept AAA30421 AAI02517 AAX09027

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca