InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ANXA2

Summary

InnateDB Gene

IDBG-646575.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA2

Gene Name

Annexin A2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009615

Encoded Proteins

IDBP-699393

Annexin A2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19965653

[Homo sapiens] ANXA2 is found in a heterotetrameric complex with S100A10, serving as a key extracellular binding partner for pathogens and host proteins alike and can also can be shed or secreted. ANXA2 tetramer can activate human and murine macrophages through TLR4 demonstrating an important role for ANXA2 in the detection of danger to the host, whether from injury or invasion.

PMID 21115493

[Homo sapiens] ANXA2 :: S100A10 is a key profibrinolytic complex that assembles plasminogen and tissue plasminogen activator, and promotes plasmin generation. As a negative feedback regulation, plasmin can induce serine phosphorylation of ANXA2 and prevents the translocation to cell surface.

PMID 21115493

[Mus musculus] Anxa2 :: S100a10 is a key profibrinolytic complex that assembles plasminogen and tissue plasminogen activator, and promotes plasmin generation. As a negative feedback regulation, plasmin can induce serine phosphorylation of Anxa2 and prevents the translocation to cell surface.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182718:
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:49860062-49904536

Strand

Forward strand

Band

Transcripts

ENSBTAT00000012655

ENSBTAP00000012655

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.

Predicted by orthology
Total	68 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004859	phospholipase inhibitor activity
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008092	cytoskeletal protein binding
GO:0019834	phospholipase A2 inhibitor activity
GO:0044548	S100 protein binding
GO:0044822	poly(A) RNA binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001765	membrane raft assembly
GO:0006900	membrane budding
GO:0030199	collagen fibril organization
GO:0031214	biomineral tissue development
GO:0031340	positive regulation of vesicle fusion
GO:0036035	osteoclast development
GO:0042730	fibrinolysis
GO:0043086	negative regulation of catalytic activity
GO:0051099	positive regulation of binding
GO:0051290	protein heterotetramerization
GO:0070509	calcium ion import
GO:0071229	cellular response to acid

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005811	lipid particle
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0019897	extrinsic component of plasma membrane
GO:0030496	midbody
GO:0031902	late endosome membrane
GO:0031988	membrane-bounded vesicle
GO:0035749	myelin sheath adaxonal region
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0043220	Schmidt-Lanterman incisure
GO:0043231	intracellular membrane-bounded organelle
GO:0045121	membrane raft
GO:0065010	extracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome