InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FER

Summary

InnateDB Protein

IDBP-699445.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FER

Protein Name

fer (fps/fes related) tyrosine kinase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053563

InnateDB Gene

IDBG-646625 (FER)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008157	protein phosphatase 1 binding
GO:0008289	lipid binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0001932	regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0006935	chemotaxis
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0010591	regulation of lamellipodium assembly
GO:0010762	regulation of fibroblast migration
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030335	positive regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0031532	actin cytoskeleton reorganization
GO:0032496	response to lipopolysaccharide
GO:0032869	cellular response to insulin stimulus
GO:0033007	negative regulation of mast cell activation involved in immune response
GO:0034446	substrate adhesion-dependent cell spreading
GO:0034614	cellular response to reactive oxygen species
GO:0035426	extracellular matrix-cell signaling
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0036119	response to platelet-derived growth factor stimulus
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038109	Kit signaling pathway
GO:0042058	regulation of epidermal growth factor receptor signaling pathway
GO:0042503	tyrosine phosphorylation of Stat3 protein
GO:0044331	cell-cell adhesion mediated by cadherin
GO:0046777	protein autophosphorylation
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0050904	diapedesis
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070102	interleukin-6-mediated signaling pathway

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001060 FCH domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016250 Tyrosine-protein kinase, Fes/Fps type
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00017
PF14633
PF00611
PF07714

PRINTS

PR00401
PR00109

PIRSF

PIRSF000632

SMART

SM00252
SM00055
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References