InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FER

Summary

InnateDB Gene

IDBG-646625.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FER

Gene Name

tyrosine-protein kinase Fer

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003051

Encoded Proteins

IDBP-699445

fer (fps/fes related) tyrosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23355730

[Mus musculus] FER is an inhibitory kinase for neutrophil chemotaxis.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151422:
Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:110465382-110864228

Strand

Forward strand

Band

Transcripts

ENSBTAT00000060973

ENSBTAP00000053563

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008157	protein phosphatase 1 binding
GO:0008289	lipid binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0001932	regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0006935	chemotaxis
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0010591	regulation of lamellipodium assembly
GO:0010762	regulation of fibroblast migration
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030335	positive regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0031532	actin cytoskeleton reorganization
GO:0032496	response to lipopolysaccharide
GO:0032869	cellular response to insulin stimulus
GO:0033007	negative regulation of mast cell activation involved in immune response
GO:0034446	substrate adhesion-dependent cell spreading
GO:0034614	cellular response to reactive oxygen species
GO:0035426	extracellular matrix-cell signaling
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0036119	response to platelet-derived growth factor stimulus
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038109	Kit signaling pathway
GO:0042058	regulation of epidermal growth factor receptor signaling pathway
GO:0042503	tyrosine phosphorylation of Stat3 protein
GO:0044331	cell-cell adhesion mediated by cadherin
GO:0046777	protein autophosphorylation
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0050904	diapedesis
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070102	interleukin-6-mediated signaling pathway

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane