Version 5.4
Homo sapiens Protein: GP6
Summary
InnateDB Protein IDBP-69955.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GP6
Protein Name glycoprotein VI (platelet)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000308782
InnateDB Gene IDBG-69953 (GP6)
Protein Structure
UniProt Annotation
Function Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. {ECO:0000269PubMed:10961879}.
Subcellular Localization Isoform 1: Cell membrane; Single-pass membrane protein.Isoform 2: Cell membrane; Single-pass membrane protein.
Disease Associations Bleeding disorder, platelet-type 11 (BDPLT11) [MIM:614201]: A mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen. {ECO:0000269PubMed:19549989, ECO:0000269PubMed:19552682}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Megakaryocytes and platelets. {ECO:0000269PubMed:10961879}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0005518 collagen binding
Biological Process
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0050900 leukocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
PFAM
PRINTS
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HCN6
PhosphoSite PhosphoSite-Q9HCN6
TrEMBL K7EIW7
UniProt Splice Variant
Entrez Gene 51206
UniGene Hs.661752
RefSeq NP_001077368
HUGO HGNC:14388
OMIM 605546
CCDS CCDS42626
HPRD 10406
IMGT
EMBL AB035073 AB043819 AB043820 AB043821 AC011476 BC104832 BC111963
GenPept AAI04833 AAI11964 BAA89353 BAB12245 BAB12246 BAB12247

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca