Version 5.4
Homo sapiens Gene: GP6
Summary
InnateDB Gene IDBG-69953.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GP6
Gene Name glycoprotein VI (platelet)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000088053
Encoded Proteins
IDBP-69955
glycoprotein VI (platelet)
IDBP-69957
glycoprotein VI (platelet)
IDBP-385227
glycoprotein VI (platelet)
IDBP-760197
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:55013705-55038264
Strand Reverse strand
Band q13.42
Transcripts
ENST00000310373 ENSP00000308782
ENST00000333884 ENSP00000334552
ENST00000417454 ENSP00000394922
ENST00000465648
ENST00000468239 ENSP00000464922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0005518 collagen binding
Biological Process
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0050900 leukocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000078810
View Gene Order
ENSBTAG00000047175
Not yet available
Pathways
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_1230
Platelet Adhesion to exposed collagen pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04512
ECM-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt Q9HCN6
TrEMBL K7EIW7
UniProt Splice Variant
Entrez Gene 51206
UniGene Hs.661752
RefSeq NM_001083899 NM_001256017 NM_016363
HUGO HGNC:14388
OMIM 605546
CCDS CCDS42626 CCDS46184 CCDS58678
HPRD
IMGT
EMBL AB035073 AB043819 AB043820 AB043821 AC011476 BC104832 BC111963
GenPept AAI04833 AAI11964 BAA89353 BAB12245 BAB12246 BAB12247
RNA Seq Atlas 51206

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca