InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ACTN1

Summary

InnateDB Protein

IDBP-699637.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTN1

Protein Name

Alpha-actinin-1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000024301

InnateDB Gene

IDBG-646802 (ACTN1)

Protein Structure

UniProt Annotation

Function

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell membrane {ECO:0000250}. Cell junction {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0003779	actin binding
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005523	tropomyosin binding
GO:0017166	vinculin binding
GO:0043495	protein anchor
GO:0044325	ion channel binding
GO:0046872	metal ion binding
GO:0051015	actin filament binding

Biological Process

GO:0043462	regulation of ATPase activity
GO:0046928	regulation of neurotransmitter secretion
GO:0048041	focal adhesion assembly
GO:0051017	actin filament bundle assembly
GO:0051234	establishment of localization
GO:0051271	negative regulation of cellular component movement
GO:0051764	actin crosslink formation

Cellular Component

GO:0001726	ruffle
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005916	fascia adherens
GO:0005925	focal adhesion
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0030018	Z disc
GO:0030054	cell junction
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001715 Calponin homology domain
IPR002017 Spectrin repeat
IPR002048 EF-hand domain
IPR014837 EF-hand, Ca insensitive
IPR018159 Spectrin/alpha-actinin
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM