Version 5.4
Bos taurus Gene: ACTN1
Summary
InnateDB Gene IDBG-646802.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACTN1
Gene Name Alpha-actinin-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018255
Encoded Proteins
IDBP-699637
Alpha-actinin-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072110:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:81023526-81121590
Strand Reverse strand
Band
Transcripts
ENSBTAT00000024301 ENSBTAP00000024301
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Predicted by orthology
Total 80 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0003779 actin binding
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005523 tropomyosin binding
GO:0017166 vinculin binding
GO:0043495 protein anchor
GO:0044325 ion channel binding
GO:0046872 metal ion binding
GO:0051015 actin filament binding
Biological Process
GO:0043462 regulation of ATPase activity
GO:0046928 regulation of neurotransmitter secretion
GO:0048041 focal adhesion assembly
GO:0051017 actin filament bundle assembly
GO:0051234 establishment of localization
GO:0051271 negative regulation of cellular component movement
GO:0051764 actin crosslink formation
Cellular Component
GO:0001726 ruffle
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005916 fascia adherens
GO:0005925 focal adhesion
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0030018 Z disc
GO:0030054 cell junction
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000072110
View Gene Order
ENSMUSG00000015143
View Gene Order
Pathways
NETPATH
REACTOME
REACT_202252
Platelet degranulation pathway
REACT_219927
Non-integrin membrane-ECM interactions pathway
REACT_214421
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
REACT_223425
Extracellular matrix organization pathway
REACT_211504
Nephrin interactions pathway
REACT_212196
Hemostasis pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_212308
Response to elevated platelet cytosolic Ca2+ pathway
REACT_214866
Cell junction organization pathway
REACT_206475
Cell-Cell communication pathway
REACT_213279
Cell-extracellular matrix interactions pathway
REACT_204848
Syndecan interactions pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_23832
Nephrin interactions pathway
REACT_20580
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_118779
Extracellular matrix organization pathway
REACT_20676
Cell junction organization pathway
REACT_163942
Syndecan interactions pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_604
Hemostasis pathway
REACT_230203
Platelet degranulation pathway
REACT_196644
Syndecan interactions pathway
REACT_224553
Hemostasis pathway
REACT_257032
Nephrin interactions pathway
REACT_206066
Extracellular matrix organization pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_243772
Cell-extracellular matrix interactions pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
REACT_255191
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04520
Adherens junction pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa04510
Focal adhesion pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05146
Amoebiasis pathway
mmu04530
Tight junction pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04520
Adherens junction pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04510
Focal adhesion pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05146
Amoebiasis pathway
INOH
PID NCI
fak_pathway
Signaling events mediated by focal adhesion kinase
ilk_pathway
Integrin-linked kinase signaling
syndecan_4_pathway
Syndecan-4-mediated signaling events
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.57772
RefSeq NM_001035351 XM_005211978
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca