InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PTGR2

Summary

InnateDB Protein

IDBP-699680.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGR2

Protein Name

Prostaglandin reductase 2

Synonyms

ZADH1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004878

InnateDB Gene

IDBG-646842 (PTGR2)

Protein Structure

UniProt Annotation

Function

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0036132	13-prostaglandin reductase activity
GO:0047522	15-oxoprostaglandin 13-oxidase activity

Biological Process

GO:0006693	prostaglandin metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal

PFAM

PF00107

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q32L99

PhosphoSite

PhosphoSite-

TrEMBL

A7E3P5

UniProt Splice Variant

Entrez Gene

506263

UniGene

RefSeq

NP_001068717

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC109688 BT030666

GenPept

AAI09689 ABS44982