Bos taurus Protein: CYCS | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-701754.2 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | CYCS | ||||||||||
Protein Name | Cytochrome c | ||||||||||
Synonyms | cytc; | ||||||||||
Species | Bos taurus | ||||||||||
Ensembl Protein | ENSBTAP00000051780 | ||||||||||
InnateDB Gene | IDBG-649069 (CYCS) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity). {ECO:0000250}. | ||||||||||
Subcellular Localization | Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | |||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | |||||||||||
InterPro |
IPR002327
Cytochrome c, class IA/ IB IPR003088 Cytochrome c domain IPR009056 Cytochrome c-like domain |
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PFAM |
PF00034
PF13442 |
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PRINTS |
PR00604
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PIRSF | |||||||||||
SMART | |||||||||||
TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | P62894 | ||||||||||
PhosphoSite | PhosphoSite-P62894 | ||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 510767 | ||||||||||
UniGene | |||||||||||
RefSeq | |||||||||||
HUGO | |||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | BC105397 | ||||||||||
GenPept | AAI05398 | ||||||||||