InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: H1F0

Summary

InnateDB Protein

IDBP-7019.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H1F0

Protein Name

H1 histone family, member 0

Synonyms

H10; H1FV;

Species

Homo sapiens

Ensembl Protein

ENSP00000344504

InnateDB Gene

IDBG-7017 (H1F0)

Protein Structure

UniProt Annotation

Function

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00837, ECO:0000269PubMed:18993075}. Chromosome {ECO:0000255PROSITE-ProRule:PRU00837, ECO:0000269PubMed:18993075}. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0031490	chromatin DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006309	apoptotic DNA fragmentation
GO:0006334	nucleosome assembly
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis

Cellular Component

GO:0000786	nucleosome
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005719	nuclear euchromatin
GO:0005794	Golgi apparatus
GO:0015629	actin cytoskeleton