InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfaip8

Summary

InnateDB Protein

IDBP-702648.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfaip8

Protein Name

Synonyms

AA987150; E130304C20Rik; ENSMUSG00000073567; Gg2-1; Gm10539; Nded; Ssc-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136030

InnateDB Gene

IDBG-146216 (Tnfaip8)

Protein Structure

UniProt Annotation

Function

Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0032611	interleukin-1 beta production
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050830	defense response to Gram-positive bacterium