InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smarca2

Summary

InnateDB Protein

IDBP-704996.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smarca2

Protein Name

Synonyms

2610209L14Rik; brahma; brm; SNF2alpha; Snf2l2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135017

InnateDB Gene

IDBG-155600 (Smarca2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	39 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	88 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0042393	histone binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006325	chromatin organization
GO:0006334	nucleosome assembly
GO:0006355	regulation of transcription, DNA-templated
GO:0008285	negative regulation of cell proliferation
GO:0030308	negative regulation of cell growth
GO:0035887	aortic smooth muscle cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0016514	SWI/SNF complex
GO:0045111	intermediate filament cytoskeleton
GO:0071778	WINAC complex

Protein Structure and Domains

PDB ID

MGI:99603

InterPro

IPR000330 SNF2-related
IPR001487 Bromodomain
IPR001650 Helicase, C-terminal
IPR006576 BRK domain
IPR012337 Ribonuclease H-like domain
IPR013999 HAS subgroup
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014012 Helicase/SANT-associated, DNA binding
IPR014978 Glutamine-Leucine-Glutamine, QLQ
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00439
PF00271
PF07533
PF07529
PF08880

PRINTS

PR00503

PIRSF

SMART

SM00297
SM00490
SM00592
SM00573
SM00487
SM00951

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q9D007

UniProt Splice Variant

Entrez Gene

67155

UniGene

Mm.490734

RefSeq

MGI ID

MGI Symbol

Smarca2

OMIM

CCDS

HPRD

IMGT

EMBL

AC118249 AC118472 AK011935 AK020092 BC004653 BC022975

GenPept

AAH04653 AAH22975 BAB27925 BAB31990