InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACMSD

Summary

InnateDB Protein

IDBP-70543.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACMSD

Protein Name

aminocarboxymuconate semialdehyde decarboxylase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000348459

InnateDB Gene

IDBG-70541 (ACMSD)

Protein Structure

UniProt Annotation

Function

Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. {ECO:0000269PubMed:19843166}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001760	aminocarboxymuconate-semialdehyde decarboxylase activity
GO:0003824	catalytic activity
GO:0046872	metal ion binding

Biological Process

GO:0006569	tryptophan catabolic process
GO:0008152	metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0046874	quinolinate metabolic process