Version 5.4
Homo sapiens Gene: ACMSD
Summary
InnateDB Gene IDBG-70541.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACMSD
Gene Name aminocarboxymuconate semialdehyde decarboxylase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000153086
Encoded Proteins
IDBP-70543
aminocarboxymuconate semialdehyde decarboxylase
IDBP-244657
aminocarboxymuconate semialdehyde decarboxylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:134838547-134902034
Strand Forward strand
Band q21.3
Transcripts
ENST00000356140 ENSP00000348459
ENST00000392928 ENSP00000376659
ENST00000485893
ENST00000498093
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001760 aminocarboxymuconate-semialdehyde decarboxylase activity
GO:0003824 catalytic activity
GO:0046872 metal ion binding
Biological Process
GO:0006569 tryptophan catabolic process
GO:0008152 metabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0046874 quinolinate metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026348
View Gene Order
ENSBTAG00000008039
Not yet available
Pathways
NETPATH
REACTOME
REACT_916
Tryptophan catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00380
Tryptophan metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655728
RefSeq NM_138326 XM_005263587 XM_005263588 XM_005263589
HUGO
OMIM
CCDS CCDS2173
HPRD 12326
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca