InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FDX1

Summary

InnateDB Protein

IDBP-70672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FDX1

Protein Name

ferredoxin 1

Synonyms

ADX; FDX; LOH11CR1D;

Species

Homo sapiens

Ensembl Protein

ENSP00000260270

InnateDB Gene

IDBG-70670 (FDX1)

Protein Structure

UniProt Annotation

Function

Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. {ECO:0000269PubMed:20547883, ECO:0000269PubMed:21636783}.

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:20547883}.

Disease Associations

Tissue Specificity

Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at protein level). {ECO:0000269PubMed:20547883}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0009055	electron carrier activity
GO:0051536	iron-sulfur cluster binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0008203	cholesterol metabolic process
GO:0042446	hormone biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process