InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOCS3

Summary

InnateDB Protein

IDBP-70678.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOCS3

Protein Name

suppressor of cytokine signaling 3

Synonyms

ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3;

Species

Homo sapiens

Ensembl Protein

ENSP00000330341

InnateDB Gene

IDBG-70676 (SOCS3)

Protein Structure

UniProt Annotation

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Note=There is some evidence that SOCS3 may be a susceptibility gene for atopic dermatitis linked to 17q25. SOCS3 messenger RNA is significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls. Furthermore, a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene has been found in two independent groups of patients.

Tissue Specificity

Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 114 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	114 [view]
Protein-Protein	110 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	2 [view]
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0007259	JAK-STAT cascade
GO:0009968	negative regulation of signal transduction
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045595	regulation of cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0060674	placenta blood vessel development
GO:0060707	trophoblast giant cell differentiation
GO:0060708	spongiotrophoblast differentiation