Homo sapiens Protein: MUC4 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-70703.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | MUC4 | ||||||||||||||||||
Protein Name | mucin 4, cell surface associated | ||||||||||||||||||
Synonyms | ASGP; HSA276359; MUC-4; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000338109 | ||||||||||||||||||
InnateDB Gene | IDBG-70699 (MUC4) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. {ECO:0000269PubMed:12102554, ECO:0000269PubMed:16049287, ECO:0000269PubMed:16814944, ECO:0000269PubMed:16914178}. | ||||||||||||||||||
Subcellular Localization | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Secreted {ECO:0000269PubMed:12102554}. Note=Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing.Mucin-4 beta chain: Cell membrane; Single- pass membrane protein.Mucin-4 alpha chain: Secreted.Isoform 3: Cell membrane; Single-pass membrane protein.Isoform 11: Secreted.Isoform 15: Secreted.Isoform 17: Cell membrane; Single-pass membrane protein. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines. {ECO:0000269PubMed:10024507, ECO:0000269PubMed:10880978, ECO:0000269PubMed:10920259, ECO:0000269PubMed:16814944}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000742
Epidermal growth factor-like domain IPR001846 von Willebrand factor, type D domain IPR003886 Nidogen, extracellular domain IPR005533 AMOP |
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PFAM |
PF00008
PF00094 PF06119 PF03782 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00181
SM00216 SM00539 SM00723 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q99102 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q99102 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 4585 | ||||||||||||||||||
UniGene | Hs.711257 | ||||||||||||||||||
RefSeq | NP_612154 | ||||||||||||||||||
HUGO | HGNC:7514 | ||||||||||||||||||
OMIM | 158372 | ||||||||||||||||||
CCDS | CCDS3311 | ||||||||||||||||||
HPRD | 11829 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC069513 AC233280 AF522031 AF522032 AF522033 AF522034 AF522035 AF522036 AF522037 AF522038 AF522039 AF522040 AF522041 AF522042 AF522043 AF522044 AF522045 AF522046 AF522047 AF522048 AF522049 AF522050 AF522051 AF522052 AF522053 AF522054 AF522055 AJ010901 AJ242541 AJ242542 AJ242543 AJ242544 AJ242545 AJ242546 AJ242547 AJ242548 AJ242549 AJ242550 AJ276359 AJ277412 AJ277505 AJ400633 AJ400849 AJ400850 AJ400851 AJ400852 AJ400853 AJ400854 AJ400855 AJ400856 AJ400857 AJ400858 AJ430032 AJ430033 AJ430034 M64594 | ||||||||||||||||||
GenPept | AAA63230 AAM66747 CAB38059 CAB81773 CAB85597 CAB85598 CAB85599 CAB85600 CAB85601 CAB85602 CAB85603 CAB85604 CAB85605 CAB85606 CAC10061 CAC10062 CAC14134 CAC14135 CAC14136 CAC14137 CAC14138 CAC14139 CAC14140 CAC14141 CAC14142 CAC14143 CAC14585 CAD22550 | ||||||||||||||||||