InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pou1f1

Summary

InnateDB Protein

IDBP-707154.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pou1f1

Protein Name

Synonyms

dw; dwarf; GHF-1; Hmp1; Pit-1; Pit1; Pit1-rs1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135113

InnateDB Gene

IDBG-170694 (Pou1f1)

Protein Structure

UniProt Annotation

Function

Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'- TAAAT-3'.

Subcellular Localization

Nucleus.

Disease Associations

Note=Defects in Pou1f1 are the cause of the dwarf (dw) phenotype which interrupts the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001708	cell fate specification
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0008340	determination of adult lifespan
GO:0021983	pituitary gland development
GO:0030183	B cell differentiation
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process
GO:0040018	positive regulation of multicellular organism growth
GO:0043567	regulation of insulin-like growth factor receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051169	nuclear transport
GO:0060126	somatotropin secreting cell differentiation
GO:0060133	somatotropin secreting cell development