Version 5.4
Homo sapiens Protein: USP36
Summary
InnateDB Protein IDBP-70925.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP36
Protein Name ubiquitin specific peptidase 36
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000310590
InnateDB Gene IDBG-70923 (USP36)
Protein Structure
UniProt Annotation
Function May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:12429849}.
Disease Associations
Tissue Specificity Broadly expressed. {ECO:0000269PubMed:14715245}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 28 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0036459 ubiquitinyl hydrolase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
PFAM PF00443
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P275
PhosphoSite PhosphoSite-Q9P275
TrEMBL K7ERC1
UniProt Splice Variant
Entrez Gene 57602
UniGene Hs.626718
RefSeq NP_079366
HUGO HGNC:20062
OMIM 612543
CCDS CCDS32755
HPRD 07164
IMGT
EMBL AB040886 AC022966 AK001671 AL833835 BC016487 BC027992 BC071582 CH471099
GenPept AAH16487 AAH27992 AAH71582 BAA91825 BAA95977 CAD38695 EAW89534 EAW89535 EAW89536

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca