InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LGALS3BP

Summary

InnateDB Protein

IDBP-71007.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGALS3BP

Protein Name

lectin, galactoside-binding, soluble, 3 binding protein

Synonyms

90K; BTBD17B; CyCAP; gp90; M2BP; MAC-2-BP; TANGO10B;

Species

Homo sapiens

Ensembl Protein

ENSP00000262776

InnateDB Gene

IDBG-71005 (LGALS3BP)

Protein Structure

UniProt Annotation

Function

Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells. {ECO:0000269PubMed:11146440, ECO:0000269PubMed:8034587, ECO:0000269PubMed:9501082}.

Subcellular Localization

Secreted. Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts. {ECO:0000269PubMed:8034587, ECO:0000269PubMed:8390986, ECO:0000269PubMed:8757764}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	85 [view]
Protein-Protein	85 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0005515	protein binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006968	cellular defense response
GO:0007155	cell adhesion
GO:0007165	signal transduction

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle