InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALDH1A1

Summary

InnateDB Protein

IDBP-71010.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDH1A1

Protein Name

aldehyde dehydrogenase 1 family, member A1

Synonyms

ALDC; ALDH-E1; ALDH1; ALDH11; HEL-9; HEL-S-53e; HEL12; PUMB1; RALDH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000297785

InnateDB Gene

IDBG-71008 (ALDH1A1)

Protein Structure

UniProt Annotation

Function

Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001758	retinal dehydrogenase activity
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0005099	Ras GTPase activator activity
GO:0005497	androgen binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0006069	ethanol oxidation
GO:0006081	cellular aldehyde metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0008218	bioluminescence
GO:0032320	positive regulation of Ras GTPase activity
GO:0042572	retinol metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process