InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ALDH1A1

Summary

InnateDB Gene

IDBG-71008.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDH1A1

Gene Name

aldehyde dehydrogenase 1 family, member A1

Synonyms

ALDC; ALDH-E1; ALDH1; ALDH11; HEL-9; HEL-S-53e; HEL12; PUMB1; RALDH1

Species

Homo sapiens

Ensembl Gene

ENSG00000165092

Encoded Proteins

IDBP-71010

aldehyde dehydrogenase 1 family, member A1

IDBP-71012

aldehyde dehydrogenase 1 family, member A1

IDBP-372896

aldehyde dehydrogenase 1 family, member A1

IDBP-372901

aldehyde dehydrogenase 1 family, member A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:72900662-73080442

Strand

Reverse strand

Band

q21.13

Transcripts

ENST00000297785	ENSP00000297785
ENST00000376939	ENSP00000366138
ENST00000419959	ENSP00000388026
ENST00000446946	ENSP00000401361
ENST00000482210
ENST00000493113
ENST00000493311

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001758	retinal dehydrogenase activity
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0005099	Ras GTPase activator activity
GO:0005497	androgen binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0006069	ethanol oxidation
GO:0006081	cellular aldehyde metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0008218	bioluminescence
GO:0032320	positive regulation of Ras GTPase activity
GO:0042572	retinol metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process