Version 5.4
Mus musculus Protein: Pum2
Summary
InnateDB Protein IDBP-710106.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pum2
Protein Name
Synonyms 5730503J23Rik; mKIAA0235; Pumm2;
Species Mus musculus
Ensembl Protein ENSMUSP00000137020
InnateDB Gene IDBG-128407 (Pum2)
Protein Structure
UniProt Annotation
Function Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Capable of deadenylation-dependent and -independent modes of repression. May be required to support proliferation and self-renewal of stem cells (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305PubMed:19861488}. Cytoplasmic granule {ECO:0000269PubMed:19861488}. Cytoplasm, perinuclear region {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells (By similarity). Colocalizes with NANOS3 in the stress granules. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Expressed in embryonic stem cells, heart, kidney, lung, skin, intestine, spleen and thymus. Expressed at intermediate level in brain and liver. Weakly or not expressed in muscles and stomach. Expressed at various stages of myeloid and lymphoid cell development. In the testis expressed in the spermatogoni, spermatocytes, spermatids and Sertoli cells. {ECO:0000269PubMed:11780640, ECO:0000269PubMed:12667987, ECO:0000269PubMed:18089289}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006417 regulation of translation
GO:0034063 stress granule assembly
Cellular Component
GO:0010494 cytoplasmic stress granule
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1931751
InterPro IPR001313 Pumilio RNA-binding repeat
IPR016024 Armadillo-type fold
PFAM PF00806
PRINTS
PIRSF
SMART SM00025
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80U58
PhosphoSite PhosphoSite-Q80U58
TrEMBL E9Q765
UniProt Splice Variant
Entrez Gene 80913
UniGene Mm.419047
RefSeq NP_001153694
MGI ID 3GVT
MGI Symbol Pum2
OMIM
CCDS CCDS49026
HPRD
IMGT
EMBL AC110382 AC134245 AF315590 AK122225 AY027917 BC013765 BC041773
GenPept AAG31805 AAH13765 AAH41773 AAK21966 BAC65507

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca