InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TFRC

Summary

InnateDB Protein

IDBP-71018.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFRC

Protein Name

transferrin receptor (p90, CD71)

Synonyms

CD71; p90; T9; TFR; TFR1; TR; TRFR;

Species

Homo sapiens

Ensembl Protein

ENSP00000353224

InnateDB Gene

IDBG-71016 (TFRC)

Protein Structure

UniProt Annotation

Function

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. {ECO:0000250, ECO:0000269PubMed:3568132}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.Transferrin receptor protein 1, serum form: Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	71 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0004998	transferrin receptor activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006508	proteolysis
GO:0006879	cellular iron ion homeostasis
GO:0006898	receptor-mediated endocytosis
GO:0016032	viral process
GO:0030316	osteoclast differentiation
GO:0033572	transferrin transport
GO:0045780	positive regulation of bone resorption
GO:0055085	transmembrane transport
GO:0097286	iron ion import

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005905	coated pit
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0042470	melanosome
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle