InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANXA1

Summary

InnateDB Protein

IDBP-71056.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA1

Protein Name

annexin A1

Synonyms

ANX1; LPC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000257497

InnateDB Gene

IDBG-71054 (ANXA1)

Protein Structure

UniProt Annotation

Function

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Basolateral cell membrane {ECO:0000250}. Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium. Found in the cytoplasm of type II pneumocytes and alveolar macrophages. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	87 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005198	structural molecule activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0005544	calcium-dependent phospholipid binding
GO:0019834	phospholipase A2 inhibitor activity
GO:0030674	protein binding, bridging
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001780	neutrophil homeostasis
GO:0006928	cellular component movement
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0018149	peptide cross-linking
GO:0030216	keratinocyte differentiation
GO:0031340	positive regulation of vesicle fusion
GO:0043066	negative regulation of apoptotic process
GO:0043086	negative regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)
GO:0046632	alpha-beta T cell differentiation
GO:0071385	cellular response to glucocorticoid stimulus
GO:0097350	neutrophil clearance
GO:2000483	negative regulation of interleukin-8 secretion

Cellular Component

GO:0001533	cornified envelope
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0009986	cell surface
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome