Version 5.4
Homo sapiens Protein: HSPB2
Summary
InnateDB Protein IDBP-71097.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPB2
Protein Name heat shock 27kDa protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000302476
InnateDB Gene IDBG-71095 (HSPB2)
Protein Structure
UniProt Annotation
Function May regulate the kinase DMPK. {ECO:0000269PubMed:9490724}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19464326}. Nucleus {ECO:0000269PubMed:19464326}. Note=Localizes to nuclear foci.
Disease Associations
Tissue Specificity Expressed preferentially in skeletal muscle and heart but not in the lens.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008047 enzyme activator activity
Biological Process
GO:0006986 response to unfolded protein
GO:0043085 positive regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001436 Alpha crystallin/Heat shock protein
IPR002068 Alpha crystallin/Hsp20 domain
IPR008978 HSP20-like chaperone
PFAM PF00011
PRINTS PR00299
PIRSF PIRSF036514
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16082
PhosphoSite PhosphoSite-Q16082
TrEMBL A8KAH6
UniProt Splice Variant
Entrez Gene 3316
UniGene Hs.709660
RefSeq NP_001532
HUGO HGNC:5247
OMIM 602179
CCDS CCDS8352
HPRD 03712
IMGT
EMBL AK293041 AY208910 BC109393 CH471065 CR457408 D89617 EF444955 EF444984 S67070 U75898
GenPept AAB28816 AAB82757 AAI09394 AAO18081 ACA05948 ACA06000 BAA24004 BAF85730 CAG33689 EAW67168 EAW67169

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca