Version 5.4
Homo sapiens Protein: HNMT
Summary
InnateDB Protein IDBP-71111.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNMT
Protein Name histamine N-methyltransferase
Synonyms HMT; HNMT-S1; HNMT-S2;
Species Homo sapiens
Ensembl Protein ENSP00000280097
InnateDB Gene IDBG-71109 (HNMT)
Protein Structure
UniProt Annotation
Function Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008170 N-methyltransferase activity
GO:0046539 histamine N-methyltransferase activity
Biological Process
GO:0002347 response to tumor cell
GO:0006972 hyperosmotic response
GO:0007420 brain development
GO:0007585 respiratory gaseous exchange
GO:0014075 response to amine
GO:0032259 methylation
GO:0035902 response to immobilization stress
GO:0042220 response to cocaine
GO:0051384 response to glucocorticoid
GO:0070555 response to interleukin-1
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043005 neuron projection
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR013217 Methyltransferase type 12
IPR016673 Histamine N-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF08242
PRINTS
PIRSF PIRSF016616
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P50135
PhosphoSite PhosphoSite-P50135
TrEMBL
UniProt Splice Variant
Entrez Gene 3176
UniGene Hs.738792
RefSeq NP_008826
HUGO HGNC:5028
OMIM 605238
CCDS CCDS2181
HPRD 05575
IMGT
EMBL AC093674 AF523356 AF523357 AF523358 AF523359 AF523360 AH012839 AK313804 BC005907 BC020677 CH471058 D16224 U08092 U44106 U44107 U44108 U44109 U44110 U44111
GenPept AAA17423 AAB18137 AAH05907 AAH20677 AAN33014 AAN33015 AAN33016 AAN33017 AAN33018 AAP42155 AAY24212 BAA03752 BAG36540 EAX11612 EAX11613 EAX11614

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca