InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNMT

Summary

InnateDB Protein

IDBP-71113.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNMT

Protein Name

histamine N-methyltransferase

Synonyms

HMT; HNMT-S1; HNMT-S2;

Species

Homo sapiens

Ensembl Protein

ENSP00000333259

InnateDB Gene

IDBG-71109 (HNMT)

Protein Structure

UniProt Annotation

Function

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	6 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046539	histamine N-methyltransferase activity

Biological Process

GO:0007585	respiratory gaseous exchange
GO:0032259	methylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P50135

PhosphoSite

PhosphoSite-P50135

TrEMBL

UniProt Splice Variant

Entrez Gene

3176

UniGene

Hs.738792

RefSeq

NP_001019246

HUGO

HGNC:5028

OMIM

605238

CCDS

CCDS33296

HPRD

05575

IMGT

EMBL

AC093674 AF523356 AF523357 AF523358 AF523359 AF523360 AH012839 AK313804 BC005907 BC020677 CH471058 D16224 U08092 U44106 U44107 U44108 U44109 U44110 U44111

GenPept

AAA17423 AAB18137 AAH05907 AAH20677 AAN33014 AAN33015 AAN33016 AAN33017 AAN33018 AAP42155 AAY24212 BAA03752 BAG36540 EAX11612 EAX11613 EAX11614