Homo sapiens Protein: LRP1B
Summary
InnateDB Protein IDBP-71210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRP1B
Protein Name low density lipoprotein receptor-related protein 1B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000374135
InnateDB Gene IDBG-71206 (LRP1B)
Protein Structure
UniProt Annotation
Function Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain. {ECO:0000269PubMed:11384978}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005041 low-density lipoprotein receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0015031 protein transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR000033 LDLR class B repeat
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal
PFAM PF00058
PF00008
PF07645
PF00057
PRINTS PR00261
PIRSF
SMART SM00135
SM00181
SM00179
SM00192
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZR2
PhosphoSite PhosphoSite-Q9NZR2
TrEMBL Q8WY27
UniProt Splice Variant
Entrez Gene 53353
UniGene Hs.656461
RefSeq NP_061027
HUGO HGNC:6693
OMIM 608766
CCDS CCDS2182
HPRD 16383
IMGT
EMBL AC010740 AC012353 AC068195 AC068287 AC073319 AC087056 AC092156 AC092575 AC093039 AC108036 AC110087 AC117947 AF176832 AF283327 AF283328 AF283329 AF283330 AF283331 AF283332 AF283333 AF283334 AF283335 AF283336 AF283337 AF283338 AF283339 AF283340 AF283341 AF283342 AF283343 AF283344 AF283345 AF283346 AF283347 AF283348 AF283349 AF283350 AF283351 AF283352 AF283353 AF283354 AF283355 AF283356 AF283357 AF283358 AF283359 AF283360 AF283361 AF283362 AF283363 AF283364 AF283366 AF283367 AF283368 AF283369 AF283370 AF283371 AF283372 AF283373 AF283374 AF283376 AF283377 AF283378 AF283379 AF283380 AF283381 AF283382 AF283383 AF283384 AF283385 AF283386 AF283387 AF283388 AF283389 AF283390 AF283391 AF283392 AF283393 AF283394 AF283395 AF283396 AF283397 AF283398 AF283399 AF283400 AF283401 AF283402 AF283403 AF283404 AF283405 AF283406 AF283407 AF283408 AF283414 AF283415 AF283416
GenPept AAF70379 AAL38107 AAL38108 AAL38109 AAL38111 AAL38112 AAX81990 AAX88846 AAX88911 AAX88968 AAX93075 AAX93103 AAX93208 AAX93243 AAY14689 AAY15024 AAY24167 AAY24318