InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CBX4

Summary

InnateDB Protein

IDBP-71258.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBX4

Protein Name

chromobox homolog 4

Synonyms

NBP16; PC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000269397

InnateDB Gene

IDBG-71254 (CBX4)

Protein Structure

UniProt Annotation

Function

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Subcellular Localization

Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	110 [view]
Protein-Protein	107 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0003727	single-stranded RNA binding
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0019899	enzyme binding
GO:0032183	SUMO binding
GO:0035064	methylated histone binding
GO:0044212	transcription regulatory region DNA binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0016568	chromatin modification
GO:0016925	protein sumoylation
GO:0043066	negative regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated