Homo sapiens Protein: SAMD4A
Summary
InnateDB Protein IDBP-7126.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAMD4A
Protein Name sterile alpha motif domain containing 4A
Synonyms SAMD4; SMAUG; SMAUG1; SMG; SMGA;
Species Homo sapiens
Ensembl Protein ENSP00000251091
InnateDB Gene IDBG-7120 (SAMD4A)
Protein Structure
UniProt Annotation
Function Acts as a translational repressor of SRE-containing messengers. {ECO:0000269PubMed:16221671}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16221671}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Enriched in synaptoneurosomes (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs, PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030371 translation repressor activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0017148 negative regulation of translation
GO:0045727 positive regulation of translation
Cellular Component
GO:0005737 cytoplasm
GO:0030054 cell junction
GO:0030425 dendrite
Protein Structure and Domains
PDB ID
InterPro IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
PFAM PF07647
PF00536
PRINTS
PIRSF
SMART SM00454
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UPU9
PhosphoSite PhosphoSite-Q9UPU9
TrEMBL
UniProt Splice Variant
Entrez Gene 23034
UniGene Hs.98259
RefSeq NP_001155048
HUGO HGNC:23023
OMIM 610747
CCDS CCDS55917
HPRD 10209
IMGT
EMBL AB028976 AF429970 AK024652 AL133444 AL138994 AL359792 BC057838 BC121173 BC121174
GenPept AAH57838 AAI21174 AAI21175 AAP97302 BAA83005